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研究業績
  1. Watanabe Y, Takakura K, Kurotani R, Abe H. Optical coherence tomography imaging for analysis of follicular development in ovarian tissue Applied Optics 2015 (19):6111-5.
  2. Cai Y, Yoneda M, Tomita T, Kurotani R, Okamoto M, Kido T, Abe H, Mitzner W, Guha A, Kimura S. Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. BMC Pulm Med. 2015 Jul 16;15:72.
  3. Kurotani R*, Shima R, Miyano Y, Sakahara S, Matsumoto Y, Shibata Y, Abe, Kimura S. SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation. Acta Histochem Cytochem. 2015 48(2):61-8. (* correspondence author)
  4. Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Singh DJ, Masuda T, Yamamoto M, Urano T, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I, and Ishikawa Y A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging Sci Rep.2015 5:9194.
  5. Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa YJ Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. Clin Invest. 2014 124(6):2785-801
  6. Hoshino S, Kurotani R*, Miyano Y, Sakahara S, Koike K, Maruyama M, Ishikawa F, Sakata I, Abe H, Sakai T Macrophage colony-stimulating factor induces prolactin expression in rat pituitary glands Zoological Science 2014 31(6):390-7. (* correspondence author)
  7. Gong Z, Yoshimura M, Aizawa S, Kurotani R, Zigman J, Sakai T, Sakata I. G-protein coupled receptor 120 (GPR120) signaling regulates ghrelin secretion in vivo and in vitro. Am J Physiol Cell Physiol- Endocrinology and Metabolism 2013 306(1):E28-35
  8. Miyano Y, Tahara S, Sakata I, Sakai T, Abe H, Kimura S, Kurotani R*. Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland Cell and Tissue Res. 2014 356(1):253-60. (*correspondence author)
  9. Miyano Y, Sakata I, Kuroda K, Aizawa S, Tanaka T, Jogahara T, Kurotani R, Sakai T. The role of the vagus nerve in the migrating motor complex and ghrelin- and motilin-induced gastric contraction in suncus. PLoS One. 2013, 8(5): e64777
  10. 黒谷玲子、浦 裕之、太組一朗DDS製剤の開発・評価と実用化手法 てんかん治療におけるDDS開発のメディカルニーズ 技術情報協会:2013 325-329
  11. Bai Y, Tsunematsu T, Jiao Q, Jin M, Cai W, Jin H, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S. Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate under both Microgravity and Hypergravity induced by Parabolic Flight Journal of Pharmacological Sciences, 119(4):381-9.
  12. Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S. Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation. J Biol Chem. 2011, 286(22):19682-19692.
  13. Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y.Identification of transcription factor E3 (TFE3) as a receptor-independent activator of G{alpha}16: Gene regulation by nuclear G{alpha} subunit and its activator. J Biol Chem. 2011 286(20):17766-76.
  14. Kurotani R, Kumaki N, Linnoila RI, Ward JM, Kimura S. Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans. Lung Cancer. 2011, 71(1):42-8.
  15. 黒谷玲子、福村英信、佐藤 格、江口晴樹、石川義弘 磁性体を利用した薬剤送達法 磁気と健康 23号2010年7月10−13頁
  16. Suzuki S, Yokoyama U, Abe T, Kiyonari H, Yamashita N, Kato Y, Kurotani R, Sato M, Okumura S, Ishikawa Y. Differential roles of EPAC in regulating cell death in neuronal and myocardial cells. J Biol Chem. 2010 285(31):24248-59.
  17. Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y. Differential Regulation of Vascular Tone and Remodeling via Stimulation of Type 2 and Type 6 Adenylyl Cyclases in the Ductus Arteriosus. Circ Res. 2010 Jun 25;106(12):1882-92. Epub 2010 Apr 29
  18. Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y. Caveolin gene transfer improves glucose metabolism in diabetic mice. Am J Physiol Cell Physiol. 2010,298(3):C450-456.
  19. Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, Minamisawa S, Lanier SM, Ishikawa Y. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: Role of gbetagamma and connexin43 (CX43). J Biol Chem. 2009 284(45):31431-31440.
  20. Shimada C, Kurotani R, Fukumura H, Ono S, Egushi H, Ishikawa Y. Drug Delivery System Using Magnetic Materials 日本病態生理学会雑誌、第18巻第1号 2009年 24-27頁
  21. Baljinnyam E*, Iwatsubo K*(*contribution equally), Kurotani R, Wang X, Ulucan C, Iwatsubo M, Lagunoff D, Ishikawa Y. Epac Increases Melanoma Migration by a Heparan Sulfate-Related Mechanism. Am J Physiol Cell Physiol. 2009, 297(4):C802-13
  22. Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC. HING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. Int J Cancer. 2009, 125(6):1306-1315.
  23. Tomita T, Kido T, Kurotani R, Iemura SI, Sterneck E, Natsume T, Vinson C, Kimura S. CAATT/enhancer binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. J Biol Chem. 2008, 283(37):25617-25627.
  24. Ishikawa Y, Kurotani R. Cardiac myosin light chain kinase: a new player in the regulation of myosin light chain in the heart. Circ Res. 2008, 102(5):516-518.
  25. Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S. Role of Secretoglobin (SCGB) 3A2 in Lung Development. Am J Respir Crit Care Med. 2008, 178(4):389-398.
  26. Okumura S, Tsunematsu T, Bai Y, Jiao Q, Ono S, Suzuki S, Kurotani R, Sato M, Minamisawa S, Umemura S, Ishikawa Y. Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight. J Appl Physiol. 2008, 105(1):173-179.
  27. Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis. 2008, 14(7):908-920.
  28. Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Circulation. 2007, 116(16):1776-1783.
  29. Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007, 134(13):2521-2531.
  30. Niimi T, Kurotani R, Kimura S, and Kitagawa Y. Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells. BBRC 2006, 349(2):588-596.
  31. Yang Q, Kurotani R, Yamada A, Kimura S and Gonzalez F.. PPAR Activation During Pregnancy Severely Impairs Mammary Lobuloal Veolar Development in Mice. Endocrinology. 2006, 147(10):4772-4780.
  32. Adachi M, Kurotani R, Morimura K, Shah Y, Sanford M, Madison BB, Gumucio DL, Marin HE, Peters JM, Young HA, Gonzalez FJ. PPAR{gamma} in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut. 2006, 55(8):1104-1113.
  33. Chiba Y,* Kurotani R* (*contribution equally), Kusakabe T, Miura T, Link BW, Misawa M, Kimura S. Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice. Am J Respir Crit Care Med. 2006, 173(9):958-964.
  34. Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon PL. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005, 280(19):19156-19165.
  35. Srisodsai A, Kurotani R, Chiba Y, Sheikh F, Young HA, Donnelly RP, Kimura S. Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. J Biol Chem. 2004, 279(52):54358-54368.
  36. Givens ML*, Kurotani R*(*contribution equally), Rave-Harel N, Miller NL, Mellon PL.Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol. 2004, 18(12):2950-2966.
  37. Tahara S, Kurotani R, Ishii Y, Sanno N, Teramoto A, Osamura RY. A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism. Mod Pathol. 2002, 15(10):1102-1105.
  38. Kurotani R, Yoshimura S, Iwasaki Y, Inoue K, Teramoto A, Osamura RY. Exogenous expression of Pit-1 in AtT-20 corticotropic cells induces endogenous growth hormone gene transcription. J Endocrinol. 2002, 172(3):477-487.
  39. Umemura S, Iwasaka T, Kakimoto K, Takahashi A, Koizumi H, Miyakawa Y, Kurotani R, Osamura RY. Expression of prolactin gene in spontaneous mammary tumors in aging Fischer 344 rats. Endocr J. 2001, 48(5):597-602.
  40. Umeoka K, Sanno N, Oyama K, Tahara S, Kurotani R, Ikuyama S, Nakashima M, Watanabe T, Osamura RY, Teramoto A. Immunohistochemical analysis of RCAS1 in human pituitary adenomas. Mod Pathol. 2001 14(12):1232-1236.
  41. Kurotani R, Yasuda M, Oyama K, Egashira N, Sugaya M, Teramoto A, Osamura RY. Expression of interleukin-6, interleukin-6 receptor (gp80), and the receptor's signal-transducing subunit (gp130) in human normal pituitary glands and pituitary adenomas. Mod Pathol. 2001, 14(8):791-797.
  42. Sanno N, Tahara S, Kurotani R, Matsuno A, Teramoto A, Osamura RY. Cytochemical and molecular biological aspects of the pituitary and pituitary adenomas-cell differentiation and transcription factors. Prog Histochem Cytochem. 2001, 36(4):263-299.
  43. Tahara S, Kurotani R, Sanno N, Takumi I, Yoshimura S, Osamura RY, Teramoto A. Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituitary adenomas. Mod Pathol. 2000, 13(10):1097-1108.
  44. Chen L, Maruyama D, Sugiyama M, Sakai T, Mogi C, Kato M, Kurotani R, Shirasawa N, Takaki A, Renner U, Kato Y, Inoue K. Cytological characterization of a pituitary folliculo-stellate-like cell line, Tpit/F1, with special reference to adenosine triphosphate-mediated neuronal nitric oxide synthase expression and nitric oxide secretion. Endocrinology. 2000, 141(10):3603-3610.
  45. Murakoshi M, Ikeda R, Horiuchi T, Nakayama K, Kurotani R, Osamura RY. Immunoreactive pit-1 protein in hyperplastic pars intermedia induced by calcitonin of the rat pituitary gland. Endocr J. 2000, 47(1):13-20.
  46. Osamura RY, Tahara S, Kurotani R, Sanno N, Matsuno A, Teramoto A. Contributions of immunohistochemistry and in situ hybridization to the functional analysis of pituitary adenomas. J Histochem Cytochem. 2000, 48(4):445-458.
  47. Osamura RY, Tahara S, Komatsubara K, Itoh Y, Kajiwara H, Kurotani R, Sanno N, Teramoto A. Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage? Pituitary. 1999, 1(3-4):269-271.
  48. Osamura RY, Kurotani R, Tahara S, Sanno N, Toshimura S, Teramoto A. 26 expression of ptx1 in the adult rat pituitary glands and pituitary cell lines -hormone secreting cells and folliculo-stellate (FS) cells. J Histochem Cytochem. 1999, 47(12):1648C-1648.
  49. Kurotani R, Tahara S, Sanno N, Teramoto A, Mellon PL, Inoue K, Yoshimura S, Osamura RY. Expression of Ptx1 in the adult rat pituitary glands and pituitary cell lines: hormone-secreting cells and folliculo-stellate cells. Cell Tissue Res. 1999, 298(1):55-61.
 
招待講演
  1. 第35回 日本磁気学会学術講演会 Symposium “Low Invasive Diagnosis and Therapy Using Magnetics”Development of cancer therapies using a novel magnetic material
     Reiko Kurotani 2011年9月28日 新潟(朱鷺メッセ)
  2. 日本生体医工学会オーガナイズドセッション 「ナノテクノロジーと物理エネルギーを融合したハイブリット標的化診断・治療」;Controlled Drug Delivery System Using a Novel Magnetic Material
     黒谷玲子 2010年6月
 
著書
  1. 最新医学 別冊「再生医学−21世紀の医学を展望する−」
    再生医学と内分泌−下垂体細胞の機能分化−
    長村 義之、黒谷 玲子、山王 なほ子、寺本 明、松野 彰(最新医学 別冊)
    株式会社 最新医学社 2000年
 
特許
Shioko Kimura, Reiko Kurotani UGRP1/SCGB3A2 AS A GROWTH FACTOR AND ANTI-APOPTOTIC AGENT U.S. Provisional Application, 登録2012年3月13日
 
受賞歴
2008年4月  財団法人 横浜総合医学振興財団 平成19年度 呼吸器疾患研究賞受賞
上向き矢印 このページの先頭へ
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